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    • CAPA Plan - BSI CE Mark Closeout
    • Index
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    • Product Verification and Validation
      • Software
      • Artificial Intelligence
      • Cybersecurity
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      • Clinical
        • Evaluation
          • Appendix
            • CV-Ana Vidal
            • CV-Antoine Giraud
            • CV-Antonio Martorrell
            • CV-Céline Fabre
            • CV-Coralie Cantarel
            • CV-Fabienne Diaz
            • CV-Jordi Barrachina
            • CV-Saray Ugidos
            • Declaration of Interests-Ana Vidal
            • Declaration of Interests-Antoine Giraud
            • Declaration of Interests-Antonio Martorell
            • Declaration of Interests-Céline Fabre
            • Declaration of Interests-Coralie Cantarel
            • Declaration of Interests-Fabienne Diaz
            • Declaration of Interests-Jordi Barrachina
            • Declaration of Interests-Saray Ugidos
          • R-TF-015-001 Clinical Evaluation Plan
          • R-TF-015-003 Clinical Evaluation Report
          • R-TF-015-011 State of the Art Legit.Health Plus
          • R-TF-015-013 Statistical Summary of Clinical Evidence
        • Investigation
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  • Legit.Health Plus Version 1.1.0.1
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  • Clinical
  • Evaluation
  • Appendix
  • CV-Antoine Giraud

Curriculum Vitae

Personal Information​

Name: Antoine Giraud Professional Title: Biostatistician Current Position: Biostatistician Institution/Organization: Horiana (Health Data Consulting) Email: antoine.giraud@horiana.com


Professional Qualifications​

Scientific Degree(s)​

  • Degree: Master's Degree in Public Health (specialty: Biostatistics) Institution: ISPED – University of Bordeaux Year: 2010

  • Degree: Bachelor's Degree in Statistics, Computer Science Applied to Insurance and Health Institution: Niort Year: 2008

  • Degree: University Degree of Statistics and Computing Institution: Niort Year: 2007

Additional Qualifications and Certifications​

  • Statistical methodologies: Study design, Statistical Analyses Plan (SAP), sample-size calculation, randomisation lists, descriptive and inferential analyses, study reporting; survival analysis (Kaplan–Meier, Cox, Fine-Gray); logistic and GLM regression; propensity scores; hypothesis testing; non-parametric tests.
  • Standards: CDISC SDTM and ADaM.
  • Languages and tools: Professional working proficiency in English; SAS (Base, Macro, Graph, Stat), STATA, R, MS-Pack Office.

MDR Annex XIV Compliance — Qualifications of Clinical Evaluators​

As per MDR 2017/745 Annex XIV Section 1, the following qualifications are confirmed:

a) Appropriate scientific education:

  • Scientific qualification: Master's Degree in Public Health (specialty: Biostatistics), ISPED – University of Bordeaux (2010).
  • Field of specialisation: Biostatistics, public health, clinical research methodology.

b) Training and experience in clinical research methodology:

  • Years of experience: 15 years in clinical trials and observational studies.
  • Methodological expertise: Statistical design and analysis of Phase I–III clinical trials and observational studies; SAP development; sample-size calculation; randomisation; CDISC ADaM/SDTM compliance.
  • Clinical-trial experience: 10 years at Bergonie Institute (a specialist oncology and sarcoma centre), covering clinical trials and national-database observational studies.

c) Competence in the relevant medical field and knowledge of the device:

  • Therapeutic-area experience: Oncology (sarcoma specialisation), gastroenterology, medical device, infectious disease, psychosocial fields.
  • Medical-device experience: Clinical-trial statistical analysis in the medical device domain (Bergonie Institute); the external methodological review engaged was scoped to a Class IIb medical device software clinical evaluation.
  • Understanding of intended use and clinical performance: The external review deliverables addressed statistical validity, study-design appropriateness, evidence ranking and adequacy of the evidence base for the intended use.

d) Understanding of regulatory requirements:

  • CDISC standards: SDTM and ADaM; applied across clinical trial submission workflows.
  • MEDDEV/MDCG: External review scope covered MEDDEV 2.7/1 Rev 4, MDCG 2020-1 (three-pillar framework) and MDCG 2020-6 Appendix III (evidence hierarchy).

Professional Experience​

Current Position​

Position: Biostatistician Institution: Horiana (Health Data Consulting), Bordeaux (France) Duration: Since November 2022

Previous Relevant Positions​

Position: Biostatistician / Data Manager Institution: Bergonie Institute, Bordeaux (France) Duration: February 2013 – October 2022 Key Responsibilities: Statistical analyses for Phase I–III clinical trials and observational studies, primarily in oncology (sarcoma) and other therapeutic areas including gastroenterology and medical devices.

Position: Database Manager Institution: Perinatal Network "Naître et Grandir", Montpellier (France) Duration: March 2012 – July 2012

Position: Statistical Studies Officer Institution: Inter Mutuelles Assistance, Niort (France) Duration: January 2011 – January 2012 Key Responsibilities: Economic analysis and statistical pricing studies.


Clinical Evaluation and Research Experience​

Experience with Medical Devices​

  • Years of experience: Statistical analysis of medical device clinical trials at Bergonie Institute; external methodological review of a Class IIb MDSW clinical evaluation (2026).
  • Regulatory experience: MEDDEV 2.7/1 Rev 4; MDCG 2020-1; MDCG 2020-6; CDISC standards.

Clinical Research Experience​

  • Phase I–III clinical trials: Extensive experience at Bergonie Institute, covering study design, SAP development, randomisation and statistical reporting.
  • Observational studies: Cohort, case-control and national-database analyses.
  • Role: Biostatistician (primary analysis, SAP, reporting).

Expertise Relevant to This Evaluation​

Technical Expertise​

  • Statistical methodology for clinical evidence: Study design, sample-size calculation, SAP development, descriptive/inferential analysis — applied to assessing whether the gathered clinical evidence is sufficient for the intended use.
  • Evidence adequacy assessment: 15 years of experience evaluating the statistical validity of primary clinical data and identifying methodological limitations.

Regulatory Knowledge​

  • MEDDEV 2.7/1 Rev 4: Clinical-evaluation methodology.
  • MDCG 2020-1: Three-pillar framework for Medical Device Software clinical evidence.
  • MDCG 2020-6 Appendix III: Hierarchical evidence ranking.
  • CDISC SDTM and ADaM: Clinical data standards for regulatory submissions.

Publications and Communications (Selected)​

Oral Communications​

  • 2025 SFA Nantes — La p-value sur la table d'opération: décryptage statistique d'un instrument interprété avec excès de confiance.

Peer-Reviewed Publications​

Full publication list available at: https://scholar.google.com/citations?user=Jgp4dfwAAAAJ&hl=fr


Languages​

  • French: Native
  • English: Professional working proficiency

Declaration​

I declare that the information provided in this curriculum vitae is accurate and complete to the best of my knowledge.

Name
Antoine Giraud
Role
Biostatistician, Horiana
Place
Bordeaux (France)
Digital Signature
[ Place Digital Signature Here ]{{Sig_es_:signer:signature}}

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CV-Antonio Martorrell
  • Personal Information
  • Professional Qualifications
    • Scientific Degree(s)
    • Additional Qualifications and Certifications
    • MDR Annex XIV Compliance — Qualifications of Clinical Evaluators
  • Professional Experience
    • Current Position
    • Previous Relevant Positions
  • Clinical Evaluation and Research Experience
    • Experience with Medical Devices
    • Clinical Research Experience
  • Expertise Relevant to This Evaluation
    • Technical Expertise
    • Regulatory Knowledge
  • Publications and Communications (Selected)
    • Oral Communications
    • Peer-Reviewed Publications
  • Languages
  • Declaration
All the information contained in this QMS is confidential. The recipient agrees not to transmit or reproduce the information, neither by himself nor by third parties, through whichever means, without obtaining the prior written permission of Legit.Health (AI Labs Group S.L.)